Scientific Publications
Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.
2021
Abbattista, M. R., Ashoorzadeh, A., Guise, C. P., Mowday, A. M., Mittra, R., Silva, S., Hicks, K. O., Bull, M. R., Jackson-Patel, V., Lin, X., Prosser, G. A., Lambie, N. K., Dachs, G. U., Ackerley, D. F., Smaill, J. B., & Patterson, A. V. Restoring tumour selectivity of the bioreductive prodrug pr-104 by developing an analogue resistant to aerobic metabolism by human aldo-keto reductase 1c3. Pharmaceuticals (2021) 14(12): 1231. https://doi.org/10.3390/ph14121231
Ahangarpour, M., Kavianinia, I., Harris, P. W. R., & Brimble, M. A. (2021). Photo-induced radical thiol-ene chemistry: A versatile toolbox for peptide-based drug design. Chemical Society Reviews (2021) 50(2): 898-944. https://doi.org/10.1039/D0CS00354A
Ahn, A., Rodger, E. J., Motwani, J., Gimenez, G., Stockwell, P. A., Parry, M., Hersey, P., Chatterjee, A., & Eccles, M. R. Transcriptional reprogramming and constitutive PD-L1 expression in melanoma are associated with dedifferentiation and activation of interferon and tumour necrosis factor signalling pathways. Cancers (2021) 13(17): 4250. https://doi.org/10.3390/cancers13174250
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Abbracchio, M. P., Alexander, W., Al-hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., Beaulieu, J. M., Bernstein, K. E., Bettler, B., Birdsall, N. J. M., Blaho, V., Boulay, F., Bousquet, C., Bräuner-Osborne, H., Burnstock, G., Caló, G., Castaño, J. P., Catt, K. J., Ceruti, S., Chazot, P., Chiang, N., Chini, B., Chun, J., Cianciulli, A., Civelli, O., Clapp, L. H., Couture, R., Csaba, Z., Dahlgren, C., Dent, G., Singh, K. D., Douglas, S. D., Dournaud, P., Eguchi, S., Escher, E., Filardo, E. J., Fong, T., Fumagalli, M., Gainetdinov, R. R., Gasparo, M. D., Gerard, C., Gershengorn, M., Gobeil, F., Goodfriend, T. L., Goudet, C., Gregory, K. J., Gundlach, A. L., Hamann, J., Hanson, J., Hauger, R. L., Hay, D. L., Heinemann, A., Hollenberg, M. D., Holliday, N. D., Horiuchi, M., Hoyer, D., Hunyady, L., Husain, A., Ijzerman, A. P., Inagami, T., Jacobson, K. A., Jensen, R. T., Jockers, R., Jonnalagadda, D., Karnik, S., Kaupmann, K., Kemp, J., Kennedy, C., Kihara, Y., Kitazawa, T., Kozielewicz, P., Kreienkamp, H. J., Kukkonen, J. P., Langenhan, T., Leach, K., Lecca, D., Lee, J. D., Leeman, S. E., Leprince, J., Li, X. X., Williams, T. L., Lolait, S. J., Lupp, A., Macrae, R., Maguire, J., Mazella, J., McArdle, C. A., Melmed, S., Michel, M. C., Miller, L. J., Mitolo, V., Mouillac, B., Müller, C. E., Murphy, P., Nahon, J. L., Ngo, T., Norel, X., Nyimanu, D., O’Carroll, A. M., Offermanns, S., Panaro, M. A., Parmentier, M., Pertwee, R. G., Pin, J. P., Prossnitz, E. R., Quinn, M., Ramachandran, R., Ray, M., Reinscheid, R. K., Rondard, P., Rovati, G. E., Ruzza, C., Sanger, G. J., Schöneberg, T., Schulte, G., Schulz, S., Segaloff, D. L., Serhan, C. N., Stoddart, L. A., Sugimoto, Y., Summers, R., Tan, V. P., Thal, D., Thomas, W., Timmermans, P. B. M. W. M., Tirupula, K., Tulipano, G., Unal, H., Unger, T., Valant, C., Vanderheyden, P., Vaudry, D., Vaudry, H., Vilardaga, J. P., Walker, C. S., Wang, J. M., Ward, D. T., Wester, H. J., Willars, G. B., Woodruff, T. M., Yao, C., & Ye, R. D. The concise guide to pharmacology 2021/22: G protein-coupled receptors. British Journal of Pharmacology (2021) 178(S1): S27-S156. https://doi.org/10.1111/bph.15538
Ameratunga, R., Longhurst, H., Steele, R., Lehnert, K., Leung, E., Brooks, A. E. S., & Woon, S.-T. Common variable immunodeficiency disorders, T-Cell responses to SARS-CoV-2 vaccines, and the risk of chronic COVID-19. The Journal of Allergy and Clinical Immunology: In Practice (2021) 9(10): 3575-3583. https://doi.org/10.1016/j.jaip.2021.06.019
Aoki, M., Gamayun, I., Wyatt, A., Grünewald, R., Simon-Thomas, M., Philipp, S. E., Hummel, O., Wagenpfeil, S., Kattler, K., Gasparoni, G., Walter, J., Qiao, S., Grattan, D. R., & Boehm, U. Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues. Science Advances (2021) 7(41): eabg4074. https://doi.org/10.1126/sciadv.abg4074
Aung, H. L., Nyunt, W. W., Fong, Y., Biggs, P. J., Winkworth, R. C., Lockhart, P. J., Yeo, T. W., Hill, P. C., Cook, G. M., & Aung, S. T. Genomic profi ling of mycobacterium tuberculosis strains, myanmar. Emerging Infectious Diseases (2021) 27(11): 2847-2855. https://doi.org/10.3201/eid2711.210726
Badii, M., Gaal, O. I., Cleophas, M. C., Klück, V., Davar, R., Habibi, E., Keating, S. T., Novakovic, B., Helsen, M. M., Dalbeth, N., Stamp, L. K., Macartney-Coxson, D., Phipps-Green, A. J., Stunnenberg, H. G., Dinarello, C. A., Merriman, T. R., Netea, M. G., Crişan, T. O., & Joosten, L. A. B. Urate-induced epigenetic modifications in myeloid cells. Arthritis Research and Therapy (2021) 23(1): 202. https://doi.org/10.1186/s13075-021-02580-1
Barzak, F. M., Ryan, T. M., Kvach, M. V., Kurup, H. M., Aihara, H., Harris, R. S., Filichev, V. V., Harjes, E., Jameson, G. B. Small-angle x-ray scattering models of apobec3b catalytic domain in a complex with a single-stranded dna inhibitor. Viruses (2021) 13(2): 290. https://doi.org/10.3390/v13020290
Blanchett, S., Tsai, C. J. Y., Sandford, S., Loh, J. M. S., Huang, L., Kirman, J. R., & Proft, T. Intranasal immunization with Ag85B peptide 25 displayed on Lactococcus lactis using the PilVax platform induces antigen-specific B- and T-cell responses. Immunology and Cell Biology (2021) 99: 767-781. https://doi.org/10.1111/imcb.12462
Blumenfeld, A., Durham, P. L., Feoktistov, A., Hay, D. L., Russo, A. F., & Turner, I. Hypervigilance, allostatic load, and migraine prevention: Antibodies to CGRP or receptor. Neurology and Therapy (2021) 10(2): 469-497. https://doi.org/10.1007/s40120-021-00250-7
Boss, A. L., Chamley, L. W., Brooks, A. E. S., & James, J. L. Differences in human placental mesenchymal stromal cells may impair vascular function in FGR. Reproduction (2021) 162(4): 319-330. https://doi.org/10.1530/REP-21-0226
Bracegirdle, J., Hou, P., Nowak, V. V., Ackerley, D. F., Keyzers, R. A., & Owen, J. G. Skyllamycins D and E, non-ribosomal cyclic depsipeptides from lichen-sourced streptomyces anulatus. Journal of Natural Products (2021) 84(9): 2536-2543. https://doi.org/10.1021/acs.jnatprod.1c00547
Burden, H. J., Adams, S., Kulatea, B., Wright-McNaughton, M., Sword, D., Ormsbee, J. J., Watene-O’Sullivan, C., Merriman, T. R., Knopp, J. L., Chase, J. G., Krebs, J. D., Hall, R. M., Plank, L. D., Murphy, R., Shepherd, P. R., & Merry, T. L. The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry. Diabetologica (2021) 2021.2002.2027.21252567. https://doi.org/10.1111/imcb.12462
Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE (2021) 16(10 October): e0258831. https://doi.org/10.1371/journal.pone.0258831
Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters (2021) 239: 60-71. https://doi.org/10.1016/j.imlet.2021.08.005
Cameron, A. J., Park, C., Howard, G. K., Harris, P. W. R., & Brimble, M. A. Total Synthesis of Allene-Containing Cyclic Tetrapeptide Pseudoxylallemycin C. Synlett (2021) 32(3): 273-276. https://doi.org/10.1055/a-1282-6870
Daniels, L. J., Annandale, M., Koutsifeli, P., Li, X., Bussey, C. T., van Hout, I., Bunton, R. W., Davis, P. J., Coffey, S., Katare, R., Lamberts, R. R., Delbridge, L. M. D., & Mellor, K. M. Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro. Nutrition and Diabetes (2021) 11(1): 8. https://doi.org/10.1038/s41387-021-00150-7
Denny, W. A., & Flanagan, J. U. Small-molecule CSF1R kinase inhibitors; review of patents 2015-present. Expert Opinion on Therapeutic Patents (2021) 31(2): 107-117. https://doi.org/10.1080/13543776.2021.1839414
Denny, W. A., & Flanagan, J. U. Inhibitors of discoidin domain receptor (Ddr) kinases for cancer and inflammation. Biomolecules (2021) 11(11): 1671. https://doi.org/10.3390/biom11111671
Dissanayake, W. C., Oh, J. K., Sorrenson, B., & Shepherd, P. R. Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin. Bioscience Reports (2021) 41(7): BSR20211066.
Fu, Z., Mowday, A. M., Smaill, J. B., Hermans, I. F., & Patterson, A. V. Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy. Cells (2021) 10(5): 1006. https://doi.org/10.3390/cells10051006
Ghanizada, H., Al-Karagholi, M. A. M., Walker, C. S., Arngrim, N., Rees, T., Petersen, J., Siow, A., Mørch-Rasmussen, M., Tan, S., O'Carroll, S. J., Harris, P., Skovgaard, L. T., Jørgensen, N. R., Brimble, M., Waite, J. S., Rea, B. J., Sowers, L. P., Russo, A. F., Hay, D. L., & Ashina, M. Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients. Annals of Neurology (2021) 89(6): 1157-1171. https://doi.org/10.1002/ana.26072
Grant-Mackie, E. S., Williams, E. T., Harris, P. W. R., & Brimble, M. A. Aminovinyl cysteine containing peptides: A unique motif that imparts key biological activity. JACS Au (2021) 1(10): 1527-1540. https://doi.org/10.1021/jacsau.1c00308
Grattan, D. R., & Andrews, Z. B. Insulin as a neuroendocrine hormone. Journal of Neuroendocrinology (2021) 33(4): e12966. https://doi.org/10.1111/jne.12966
Hampe, L., Harris, P. W. R., Rushton, B., Radjainia, M., Brimble, M. A., & Mitra, A. K. Engineering a stable complex of ERp44 with a designed peptide ligand for analyzing the mode of interaction of ERp44 with its clients. Peptide Science (2021) e24230. https://doi.org/10.1002/pep2.24230
Hanna, C. C., Hermant, Y. O., Harris, P. W. R., & Brimble, M. A. Discovery, Synthesis, and Optimization of Peptide-Based Antibiotics. Accounts of Chemical Research (2021) 54(8): 1878-1890. https://doi.org/10.1021/acs.accounts.0c00841
Hermant, Y., Palpal-Latoc, D., Kovalenko, N., Cameron, A. J., Brimble, M. A., & Harris, P. W. R. The total chemical synthesis and biological evaluation of the cationic antimicrobial peptides, laterocidine and brevicidine. Journal of Natural Products (2021) 84(8): 2165-2174. https://doi.org/10.1021/acs.jnatprod.1c00222
Horne, C. R., Venugopal, H., Panjikar, S., Wood, D. M., Henrickson, A., Brookes, E., North, R. A., Murphy, J. M., Friemann, R., Griffin, M. D. W., Ramm, G., Demeler, B., & Dobson, R. C. J. Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Nature Communications (2021) 12(1): 1988. https://doi.org/10.1038/s41467-021-22253-6
Kasim, J. K., Kavianinia, I., Bull, M., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A. Fourth-Generation Analogues of the Anticancer Peptaibol Culicinin D: Probing the Effects of Hydrophobicity and Halogenation on Cytotoxicity. Synthesis (Germany) (2021) 53: A-G. https://doi.org/10.1055/s-0040-1706264
Khant Aung, Z., Kokay, I. C., Grattan, D. R., & Ladyman, S. R. Prolactin-induced adaptation in glucose homeostasis in mouse pregnancy is mediated by the pancreas and not in the forebrain. Frontiers in Endocrinology (2021) 12: 765976. https://doi.org/10.3389/fendo.2021.765976
Kovalenko, N., Howard, G. K., Swain, J. A., Hermant, Y., Cameron, A. J., Cook, G. M., Ferguson, S. A., Stubbing, L. A., Harris, P. W. R., & Brimble, M. A. A concise synthetic strategy towards the novel calcium-dependent lipopeptide antibiotic, malacidin a and analogues. Frontiers in Chemistry (2021) 9: 687875. https://doi.org/10.3389/fchem.2021.687875
Ladyman, S. R., & Brooks, V. L. Central actions of insulin during pregnancy and lactation. Journal of Neuroendocrinology (2021) 33(4): e12946. https://doi.org/10.1111/jne.12946
Ladyman, S. R., Carter, K. M., Gillett, M. L., Aung, Z. K., & Grattan, D. R. A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin. eLife (2021) 10: e62260. https://doi.org/10.7554/eLife.62260
Ladyman, S. R., Larsen, C. M., Taylor, R. S., Grattan, D. R., & McCowan, L. M. E. Case–control study of prolactin and placental lactogen in SGA pregnancies. Reproduction and Fertility (2021) 2(4): 244-250. https://doi.org/10.1530/RAF-21-0020
Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. Breast Cancer Patient Prognosis Is Determined by the Interplay between TP53 Mutation and Alternative Transcript Expression: Insights from TP53 Long Amplicon Digital PCR Assays. Cancers (Basel) (2021) 13(7): 1531. https://doi.org/10.3390/cancers13071531
Lee, B. S., Hards, K., Engelhart, C. A., Hasenoehrl, E. J., Kalia, N. P., Mackenzie, J. S., Sviriaeva, E., Chong, S. M. S., Manimekalai, M. S. S., Koh, V. H., Chan, J., Xu, J., Alonso, S., Miller, M. J., Steyn, A. J. C., Grüber, G., Schnappinger, D., Berney, M., Cook, G. M., Moraski, G. C., & Pethe, K. Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. EMBO Molecular Medicine (2021) 13(1): e13207. https://doi.org/10.15252/emmm.202013207
Lee, B. Y. T., Sullivan, M. P., Yano, E., Tong, K. K. H., Hanif, M., Kawakubo-Yasukochi, T., Jamieson, S. M. F., Soehnel, T., Goldstone, D. C., & Hartinger, C. G. Anthracenyl functionalization of half-sandwich carbene complexes: In vitro anticancer activity and reactions with biomolecules. Inorganic Chemistry (2021) 60(19): 14636-14644. https://doi.org/10.1021/acs.inorgchem.1c01675
Lee, K., Vakili, S., Burden, H. J., Adams, S., Smith, G. C., Kulatea, B., Wright-McNaughton, M., Sword, D., Watene-O’Sullivan, C., Atiola, R. D., Paul, R. G., Plank, L. D., Wilcox, P., Kallingappa, P., Merriman, T. R., Krebs, J. D., Hall, R. M., Murphy, R., Merry, T. L., & Shepherd, P. R. The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition. Molecular Metabolism (2021) 59:101464. http:doi.org/10.1016/j.molmet.2022.101464
Li, H., Clarke, G. S., Christie, S., Ladyman, S. R., Kentish, S. J., Young, R. L., Gatford, K. L., & Page, A. J. Pregnancy-related plasticity of gastric vagal afferent signals in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology (2021) 320(2): G183-G192. https://doi.org/10.1152/ajpgi.00357.2020
Loef, E. J., Sheppard, H. M., Birch, N. P., & Dunbar, P. R. Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells. Frontiers in Immunology (2021) 12: 628090. https://doi.org/10.3389/fimmu.2021.628090
Loh, J. M. S., Rivera-Hernandez, T., McGregor, R., Khemlani, A. H. J., Tay, M. L., Cork, A. J., M. Raynes, J., Moreland, N. J., Walker, M. J., & Proft, T. A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Report (2021) 11(1): 4353. https://doi.org/10.1038/s41598-021-83673-4
Lorenz, N., Ho, T. K., McGregor, R., Davies, M. R., Williamson, D. A., Gurney, J. K., Smeesters, P. R., Baker, M. G., & Moreland, N. J. Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. Clinical Infectious Diseases (2021) ciab180. https://doi.org/10.1093/cid/ciab180
Lu, B. L., Li, F. F., Kelch, I. D., Williams, G. M., Dunbar, P. R., & Brimble, M. A. Investigating the individual importance of the Pam2Cys ester motifs on TLR2 activity. European Journal of Organic Chemistry (2021) 2021(39): 5415-5423. https://doi.org/10.1002/ejoc.202101055
Masson, S. W. C., Woodhead, J. S. T., D'Souza, R. F., Broome, S. C., MacRae, C., Cho, H. C., Atiola, R. D., Futi, T., Dent, J. R., Shepherd, P. R., & Merry, T. L. β-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake. Journal of Physiology (2021) 599: 3897-3912. https://doi.org/10.1113/jp281352
McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology (2021) 11: 709540. https://doi.org/10.3389/fonc.2021.709540
McGregor, R., Tay, M. L., Carlton, L. H., Hanson-Manful, P., Raynes, J. M., Forsyth, W. O., Brewster, D. T., Middleditch, M. J., Bennett, J., Martin, W. J., Wilson, N., Atatoa Carr, P., Baker, M. G., & Moreland, N. J. Mapping Autoantibodies in Children With Acute Rheumatic Fever. Frontiers in Immunology (2021) 12(2883): 702877. https://doi.org/10.3389/fimmu.2021.702877
McHugh, A. D., Chase, J. G., Knopp, J. L., Ormsbee, J. J., Kulawiec, D. G., Merry, T. L., Murphy, R., Shepherd, P. R., Burden, H. J., & Docherty, P. D. The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters. Journal of Diabetes Science and Technology (2021) 16(4). https://doi.org/10.1177/1932296820986878
McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M. CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. Molecular Microbiology (2021) 116: 1033-1043. https://doi.org/10.1111/mmi.14790
Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., Bourdon, J. C., & Braithwaite, A. W. Adaptive homeostasis and the p53 isoform network. EMBO Reports (2021) 22(12): e53085. https://doi.org/10.15252/embr.202153085
Mountjoy, K. G. ELISA versus LUMINEX assay for measuring mouse metabolic hormones and cytokines: sharing the lessons I have learned. Journal of Immunoassay and Immunochemistry (2021) 42(2): 154-73. https://doi.org/10.1080/15321819.2020.1838924
Mowday, A. M., Dubois, L. J., Kubiak, A. M., Chan-Hyams, J. V. E., Guise, C. P., Ashoorzadeh, A., Lambin, P., Ackerley, D. F., Smaill, J. B., Minton, N. P., Theys, J., & Patterson, A. V. Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer Gene Therapy (2021) 29,178–188. https://doi.org/10.1038/s41417-021-00296-7
Oliver, M. R., Horne, C. R., Shrestha, S., Keown, J. R., Liang, L. Y., Young, S. N., Sandow, J. J., Webb, A. I., Goldstone, D. C., Lucet, I. S., Kannan, N., Metcalf, P., & Murphy, J. M. Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. Nature Communications (2021) 12(1): 1002. https://doi.org/10.1038/s41467-021-21191-7
Ormsbee, J. J., Burden, H. J., Knopp, J. L., Chase, J. G., Murphy, R., Shepherd, P. R., & Merry, T. Variability in Estimated Modelled Insulin Secretion. Journal of Diabetes Science and Technology (2021) 16(3). https://doi.org/10.1177/1932296821991120
Painter, G. F., Burn, O. K., & Hermans, I. F. Using agonists for iNKT cells in cancer therapy. Molecular Immunology (2021) 130: 1-6. https://doi.org/10.1016/j.molimm.2020.12.010
Park, S. M., Brooks, A. E. S., Chen, C. J. J., Sheppard, H. M., Loef, E. J., McIntosh, J. D., Angel, C. E., Mansell, C. J., Bartlett, A., Cebon, J., Birch, N. P., & Dunbar, P. R. Migratory cues controlling B-lymphocyte trafficking in human lymph nodes. Immunology and Cell Biology (2021) 99(1): 49-64. https://doi.org/10.1111/imcb.12386
Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., Sevcnikar, B., Furtmüller, P. G., Traxlmayr, M. W., Obinger, C., Eccles, M. R., & Winterbourn, C. C. Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology (2021) 46: 102090. https://doi.org/10.1016/j.redox.2021.102090
Pilapitiya, D. H., Harris, P. W. R., Hanson-Manful, P., McGregor, R., Kowalczyk, R., Raynes, J. M., Carlton, L. H., Dobson, R. C. J., Baker, M. G., Brimble, M., Lukomski, S., & Moreland, N. J. Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients. Pathogens and Disease (2021) 79(6): ftab033. https://doi.org/10.1093/femspd/ftab033
Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A. Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal (2021) 35(2): e21216. https://doi.org/10.1096/fj.202001147r
Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., Merry, T. L., & Lee, C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications (2021) 12(1): 470. https://doi.org/10.1038/s41467-020-20790-0
Safarian, S., Opel-Reading, H. K., Wu, D., Mehdipour, A. R., Hards, K., Harold, L. K., Radloff, M., Stewart, I., Welsch, S., Hummer, G., Cook, G. M., Krause, K. L., & Michel, H. The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications (2021) 12(1): 5236. https://doi.org/10.1038/s41467-021-25537-z
Shepperson, O. A., Cameron, A. J., Wang, C. J., Harris, P. W. R., Taylor, J. A., & Brimble, M. A. Thiol-ene enabled preparation of S -lipidated anti-HBV peptides. Organic and Biomolecular Chemistry (2021) 19(1): 220-232. https://doi.org/10.1039/d0ob01997f
Sorrenson, B., Dissanayake, W. C., Hu, F., Lee, K. L., & Shepherd, P. R. A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochemical Journal (2021) 478(8): 1605-1615. https://doi.org/10.1042/bcj20200862
Stevenson, L. J., Bracegirdle, J., Liu, L., Sharrock, A. V., Ackerley, D. F., Keyzers, R. A., & Owen, J. G. Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway. RSC Chemical Biology (2021) 2(2): 556-567. https://doi.org/10.1039/d0cb00228c
Suresh, V. Permeability properties of an in vitro model of the alveolar epithelium. Cellular and Molecular Bioengineering (2021) 14(6): 653-659. https://doi.org/10.1007/s12195-021-00690-z
Tong, J. T. W., Harris, P. W. R., Brimble, M. A., & Kavianinia, I. An insight into FDA approved antibody-drug conjugates for cancer therapy. Molecules (2021) 26(19): 5847. https://doi.org/10.3390/molecules26195847
Tong, K. K. H., Hanif, M., Movassaghi, S., Sullivan, M. P., Lovett, J. H., Hummitzsch, K., Söhnel, T., Jamieson, S. M. F., Bhargava, S. K., Harris, H. H., & Hartinger, C. G. Triazolyl-functionalized N-heterocyclic carbene half-sandwich compounds: Coordination mode, reactivity and in vitro anticancer activity. ChemMedChem (2021) 16(19): 3017-3026. https://doi.org/10.1002/cmdc.202100311
Tran, K. B., Gimenez, G., Tsai, P., Kolekar, S., Rodger, E. J., Chatterjee, A., Jabed, A., Shih, J. H., Joseph, W. R., Marshall, E. S., Wang, Q., Print, C. G., Eccles, M. R., Baguley, B. C., & Shepherd, P. R. Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma. Pigment Cell and Melanoma Research (2021) 34(1): 136-143. https://doi.org/10.1111/pcmr.12908
Tran, K. B., Kolekar, S., Jabed, A., Jaynes, P., Shih, J. H., Wang, Q., Flanagan, J. U., Rewcastle, G. W., Baguley, B. C., & Shepherd, P. R. Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK. BMC Cancer (2021) 21(1): 136. https://doi.org/10.1186/s12885-021-07826-4
Webby, M. N., Herr, N., Bulloch, E. M. M., Schmitz, M., Keown, J. R., Goldstone, D. C., & Kingston, R. L. Structural analysis of the menangle virus p protein reveals a soft boundary between ordered and disordered regions. Viruses (2021) 13(9): 1737. https://doi.org/10.3390/v13091737
Wilson, Z. E., & Brimble, M. A. Molecules derived from the extremes of life: A decade later. Natural Product Reports (2021) 38(1): 24-82. https://doi.org/10.1039/d0np00021c
Xiang, S., Song, S., Tang, H., Smaill, J. B., Wang, A., Xie, H., & Lu, X. TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery. Drug Discovery Today (2021) 26(10): 2445-2455. https://doi.org/10.1016/j.drudis.2021.05.016
Yim, V., Hermant, Y. O., Harris, P. W. R., & Brimble, M. A. Synthesis of lipopeptides by CLipPA chemistry. In W. M. Hussein, R. J. Stephenson, & I. Toth (Eds.), Peptide Conjugation: Methods and Protocols (2021) pp. 253-263. Springer US. https://doi.org/10.1007/978-1-0716-1617-8_19
Zhang, W., Kaplan, A. R., Davison, E. K., Freeman, J. L., Brimble, M. A., & Wuest, W. M. Building: Trans -bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: The case for antibiotic development. Natural Product Reports (2021) 38(5): 880-889. https://doi.org/10.1039/d0np00052c